Recovery of locked-in syndrome in central pontine myelinolysis
نویسندگان
چکیده
We read, with great interest, the article “Recovery of lockedin syndrome following liver transplantation with calcineurin inhibitor cessation and supportive treatment” by El Moghazy et al. [1]. The authors present an important clinical observation on a favorable recovery of locked-in syndrome due to central pontine myelinolysis (CPM) in association with liver transplantation, hyponatremia, and use of tacrolimus. By presenting a similar case vignette of CPM, we wish to emphasize the hypothesis that recovery is possible and the outcome is not always dismal.
منابع مشابه
A Step-Wise Multidisciplinary Rehabilitation Approach of Central Pontine and Extra Pontine Myelinosis in Locked-In Syndrome: A Case Report
Central Pontine Myelinosis (CPM) and Extra Pontine Myelinosis (EPM) are debilitating conditions, resulting from the rapid correction of hyponatremia. The outcome and prognosis of this medical condition are variable; mainly involving functional decline from neuro-musculoskeletal upset. An intensive, multidisciplinary rehabilitation has played an essential role in facilitating and hasten recovery...
متن کاملRecovery of locked-in syndrome following liver transplantation with calcineurin inhibitor cessation and supportive treatment
BACKGROUND Locked-in syndrome represents the most severe form of central pontine myelinolysis (CPM) and has been associated with a dismal outcome. CASE REPORT In this report we describe a case of severe locked-in syndrome after liver transplantation with spontaneous recovery with cessation of calcneurin inhibitor therapy and supportive treatment. A 54-year old male received deceased-donor liv...
متن کاملCentral pontine myelinolysis.
Central pontine myelinolysis (CPM), a neurologic disorder caused most frequently by rapid correction of hyponatremia, is characterized by demyelination that affects the central portion of the base of the pons. There are no inflammatory changes, and blood vessels are normal. Clinical features usually reflect damage to the descending motor tracts and include spastic tetraparesis, pseudobulbar par...
متن کاملLocked-in Syndrome due to Central Pontine Myelinolysis: Case Report
Central pontine myelinolysis (CPM) classically occurs in alcoholics, malnourished individuals, chronic liver diseases, and rapid correction of hyponatremia. This report presents locked-in syndrome due to CPM following rapid correction of hyponatremia. A 44-year-old male came to the hospital due to a short period of loss of consciousness. He was alert and had no focal neurological abnormalities ...
متن کاملResolving MR features in osmotic myelinolysis (central pontine and extrapontine myelinolysis).
Osmotic myelinolysis is a distinctive clinical syndrome with characteristic MR features in the central pons (central pontine myelinolysis) and in other locations (extrapontine myelinolysis). We describe the resolving MR features in an adolescent who has experienced complete neurologic recovery. Regions of involvement manifested increased T2 signal intensity. The extrapontine involvement was not...
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عنوان ژورنال:
دوره 14 شماره
صفحات -
تاریخ انتشار 2013